Female Swiss albino mice were inoculated with 2.5 x 106 Ehrlich ascites carcinoma (EAC) cells into the right femoral region, and the tumor size determined on consecutive days, starting on the 8th day after inoculation until the 35th day. The control group received phosphate buffered saline (PBS), and the BioBran group received 40 mg/kg body weight of BioBran intraperitoneally three times a week for a period of 3 weeks, starting on the 8th day after the inoculation of EAC. After treatment, the tumor size was determined. The results showed a significantly greater suppression of tumor growth in the BioBran group compared to the control (PBS) group, starting on the 14th day after inoculation of EAC. The photographs of tumor on the 35th day also showed a tumor regression in the BioBran group.
Ghoneum M., et al, “In vivo Tumor Inhibitory Effects of Nutritional Rice Bran Supplement MGN-3/Biobran on Ehrlich Carcinoma-Bearing Mice”, Nutrition and Cancer, 2008