Effect of Bacillus subtilis var. natto-derived protein on the human blood coagulation/fibrinolysis system

A total of 23 adults, including patients with metabolic diseases related to thrombosis, were given 250mg NKCP for two consecutive months. Coagulation/fibrinolysis parameters and symptoms were evaluated 1 and 2 months after starting treatment.
Euglobulin lysis time (ELT) significantly decreased from the baseline value at 1 and 2 months, and t-PA significantly increased at 2 months, showing the accelerated fibrinolysis system. However, the measured ELT and t-PA values were within the normal ranges. Fibrinogen degradation products (FDP) significantly decreased 1 month after starting ingestion but returned to the baseline value at 2 months.
Symptoms of shoulder stiffness significantly improved from baseline at 1 and 2 months.

Journal of the Japanese Society of Biorheology 2004; 18 (1)