Biobran (MGN-3) acts through toll-like receptor-4 (TRL-4) and reverses the detrimental effects of hyperglycaemia on phagocytosis

04 June 2023 – 09 June 2023, Waterville Valley, New Hampshire, United States.

Shah, Sana, El Mohtadi, Mohamed and Ashworth, Jason

Biobran (MGN-3) enhances host-pathogen interaction in an in vitro hyperglycaemic model of an infected diabetic foot ulcer

04 June 2023 – 09 June 2023, Waterville Valley, New Hampshire, United States.

Shah, Sana, El Mohtadi, Mohamed and Ashworth, Jason

Biobran (MGN-3) concurrently reverses lipopolysaccharide-induced elevation of CD14 and impairment of macrophage-mediated bacterial clearance in a model of diabetic wound biofilms

04 June 2023 – 09 June 2023, Waterville Valley, New Hampshire, United States.

Asif, Mohammed Subhan, El Mohtadi, Mohamed and Ashworth, Jason

“Determining the cellular and molecular mechanisms by which Biobran (MGN-3) mediates innate immunity in a hyperglycaemic model of a diabetic foot ulcer infection”

04 June 2023 – 09 June 2023, Waterville Valley, New Hampshire, United States.

Shah, Sana, El Mohtadi, Mohamed and Ashworth, Jason

“From Bench to Bedside: The Role of Arabinoxylan Rice Bran (MGN-3/Biobran) in Cancer Immunotherapy”

Convention Cernter Medical Campus Tanta Unibersity Tanta, Egypt

M. Ghoneum

“Prevention of hepatocarcinogenesis in rats by arabinoxylan rice bran, MGN-3/Biobran”

AACR Annual Meeting 2016, New Orleans, USA

N. K. Badr El-Din, Doaa A. Ali,　R. Othman, M. Ghoneum

“Effects of indigestible polysaccharides on obesity related metabolic diseases and inflammation”

251st American Chemical Society National Meeting & Exposition, San Diego, USA

Y. Egashira

“Biobran/MGN-3, arabinoxylan from rice bran, sensitizes breast adenocarcinoma tumor cells to paclitaxol in mice”

American Association for Cancer Research, Annual Meeting, Philadelphia, USA

M. Ghoneum (Drew University of Medicine and Science), et al

“From bench to bedside: The use of arabinoxylan rice bran (MGN-3/Biobran) in cancer medicine”

The 1st Annual Meeting (The Middle-Eastern Association for Cancer Research), Tanta, Egypt
M. Ghoneum (UCLA/Drew University of Medicine and Science)

“The Effect of Rice Bran Arabinoxylan Compound on Glucose Metabolism in Skeletal Muscle”

American Physiological Society International Meeting, Denver, USA
F. Kimura (Tsukuba University), et al

“RBAC, a modified form of Arabinoxylan from rice bran, impairs prostate cancer cell line proliferation, adhesion, and invasion in vitro”

101st Annual Meeting for the American Associate for Cancer Research, Washington, USA
K. Ali (Pharmacognosia), et al

“THE EFFICACY OF BIOBRAN, ARABINOXYLAN COMPOUND DERIVED FROM RICE BRAN, IN PATIENTS WITH IRRITABLE BOWEL SYNDROME”

GASTRO 2009 UEGW/WCOG, London, UK
T. Kamiya (Nagoya City University), et al

“Study on the Active Ingredients and Mechanism of BioBran (MGN-3) in Inhibiting D-Galactosamine-Induced Liver Damage”

14th meeting of Japanese Association for Dietary Fiber Research, Gifu, Japan
Y. Egashira (Chiba University), et al

“Effects Of Rice Bran Arabinoxylan Compound On Gut Immunity In Response To Exhaustive Intense Exercise”

Japanese Society of Physical Fitness and Sports Medicine, Niigata, Japan
F. Kimura (Tsukuba University), et al

“Effects Of Rice Bran Arabinoxylan Compound On Intense Exercise-induced Secretory Immunoglobulin A Suppression In Rats”

American College of Sports Medicine 2009 Annual Meeting, Seattle, USA
F. Kimura (Tsukuba University), et al

“Effects Of Rice Bran Arabinoxylan Compound On Gut Immunity In Response To Exhaustive Intense Exercise”

American College of Sports Medicine 2009 Annual Meeting, Seattle, USA
K. Shimizu (Waseda University), et al

“The Anti-inflammatory and Immunomodulating Effects of Rice Bran Arabinoxylan Compound on Irritable Bowel Syndrome”

The 50th Annual Meeting of the Japanese Society of Gastroenterology Journal of Gastroenterology, Tokyo, Japan
T. Kamiya, M. Shikano and T. Joh (Nagoya City University)

“Rice Bran Supplement (MGN-3/Biobran) Suppresses Tumor Growth via Modulating Cytokine Production and Increasing Apoptotic Level in Ehrlich Carcinoma-bearing Mice”

Federation of Clinical Immunology Society (FOCiS2007), San Diego, USA
M. Ghoneum (UCLA/Drew University of Medicine and Science), et al

“Phytonutrient-Therapy and Immune System Support for Patients with Hormone-Refractory Prostate Cancer”

3rd Annual Anti-Aging Conference London 2006, London, UK
B.L Pfeifer (Aeskular Cancer Centre)

“In Vivo Tumor Inhibitory Effects of Arabinoxylan Rice Bran (MGN-3/biobran) on Ehrlich Carcinoma-Bearing Mice”

International Research Conference on Food and Cancer, Washington D.C., USA
M. Ghoneum (UCLA/Drew University of Medicine and Science), et al

“Effect of Modified Arabinoxylan from Rice Bran(MGN-3/Biobran)On Human Neutrophils and Monocyte Functions In Vitro”

Federation of Clinical Immunology Societies Annual Meeting, San Francisco, USA
M. Ghoneum (UCLA/Drew University of Medicine and Science), et al

“Improving effect of hydrolyzed rice bran on diabetic rats given high-carbohydrate feed”

The 59th Annual Meeting of the Japanese Society of Nutrition and Food Science, Tokyo, Japan
N. Kitamura, I. Ohara (Aichi Gakusen University), et al

“Immunomodulatory Activity of Enzyme-treated Rice Bran Hemicellulose”

Japanese Association for Dietary Fiber Research, Chiba, Japan
T. Miura (Hirosaki University, School of Medicine) and Y. Kato (Faculty of Education, Hirosaki University), et al

“Chemical Structure of Immunostimulating Substances from Rice Bran”

2004 Annual Meeting of the Japanese Society of Applied Glycoscience and 12th Symposium on Amylases and Related Enzymes, Kagoshima, Japan
T. Miura, M. Chiba,  Y. Miyazaki, Y. Kato (Hirosaki University), et al.

“Hydrolyzed Rice Bran Reduces the Aggravation of Protein Metabolism in the Streptozotocin-Induced Diabetic Rats”
American College of Nutrition, 45th Annual Meeting, Long Beach, USA
N. Kitamura, I. Ohara (Aichi Gakusen University),  et al

“The Oral Administration of Hydrolyzed Rice Bran Prevents the Common Cold Syndrome in the Elderly”

21st Symposium of Medical and Pharmaceutical Society for WAKAN-YAKU, Toyama, Japan
K. Omura (Dokkyo University School of Medicine), K. Ichihashi (Ichihashi Clinic),  T. Fujie (Atreju Uosaki),  M. Kudo, X. Zhu (Daiwa Pharmaceutical Co., Ltd.),  K. Tazawa (Toyama Medical and Pharmaceutical University) et al

“Evaluation of the Effect of Hydrolyzed Rice Bran on Reducing Respiratory Symptom in the Smokers”

21st Symposium of Medical and Pharmaceutical Society for WAKAN-YAKU, Toyama, Japan
K. Omura (Dokkyo University School of Medicine, Department of Legal Medicine), M. Kudo (Daiwa Pharmaceutical Co., Ltd.), N. Nakamichi (The Jikei University, N.S. Clinic) et al

“Modified arabinoxylan rice bran (MGN-3/Biobran), Potentiates Chemotherapy-induced Apoptosis in Human Breast Cencer Cells”

International Research Conference on Food, Nutrition and Cancer, Washington D.C., USA
M. Ghoneum (UCLA/Drew University of Medicine and Science), et al

“Effect of the Oral Administration of Hydrolyzed Rice Bran (HRB) on the Common Cold Syndrome in the Elderly”

4th Conference of Japanese Society of Anti-Aging Medicine, Tokyo, Japan
K. Omura (Dokkyo University School of Medicine), K. Ichihashi (Ichihashi Clinic), K. Tazawa (Toyama Medical and Pharmaceutical University)

“Modified arabinoxylan rice bran (MGN-3/Biobran) potentiates apoptosis in cancer cells induced by multiple anti-cancer agents in vitro”

7th International Symposium on Predictive Oncology & Intervention Strategies, Nice, France
Ghoneum M. (UCLA/Drew University of Medicine and Science) and S. Gollapudi (University of California Irvine)

“The effect in the physiological function of a Modified Arabinoxylan Rice Bran”

Japan Society for Biological Therapy, Toyama, Japan
M. Masada (Chiba University), K. Tazawa (Toyama Medical and Pharmaceutical University) et al

“Effect of Rice Bran Arabinoxylan and Shark Lipid Extract on Complementary and Alternative Therapy”

7th Conference of Japanese Association for Alternative, Complementary and Traditional Medicine (JACT), Kobe, Japan
T. Omori (Ginza San Espero Omori Clinic)

“A Novel Approach to Breast Cancer Therapy: Modified Arabinoxylan Rice Bran (MGN-3/Biobran) Enhances Apoptosis of Human Breast Cancer Cells Following Phagocytosis of Saccharomyces Cerevisiae, the Baker’s Yeast, in vitro”

American Association for Cancer Research, Huntington Beach, USA
M.Ghoneum (UCLA/Drew University of Medicine and Science) and S. Gollapudi (University of California Irvine)

“Immunoactivation therapy for various progressive cancers using rice bran arabinoxylan derivative (Bio Bran)”

The Japanese Society for Complementary and Alternative Medicine, Sendai, Japan
H. Tsunekawa (Tsunekawa Gastrointestinal Clinic) et al

“Effect of Enzyme-processed Rice Bran Hemicellulose (MGN-3) on Experimental Liver Dysfunction in Rats”

7th Conference of Japanese Association for Dietary Fiber Research, Tokyo, Japan
T. Yamada, A. Daizou, K. Poindoglun (Graduate School of Science and Technology, Chiba University), K. Egashira,  H. Sanada (Department of Bioresources Chemistry, Chiba University) et al

“Significance of asthmatic mouse model exposed to antigen (Toluene Diisocyanate) for a prolonged period”

52nd Conference of Japanese Society of Allergology, Yokohama, Japan
H. Kanbayashi, Y. Endo (McMaster University)

“Evaluation of the effects of asthma prevention and symptom reduction by enzymatically modified rice-bran foods in asthmatic model mice”

52nd Conference of Japanese Society of Allergology, Yokohama, Japan
H. Kanbayashi, Y. Endo (McMaster University)

“A new approach to regulating cytokine production”

The 1st International Symposium of The Institute of Functional Biomaterials and Biotechnology, Seoul, Korea
S. Nonoyama (National Defense Medical College)

“Normalization of the Lymphocyte System in Peripheric Blood Reaction by Arabinoxylan from Rice Bran (MGN-3)”

43rd Annual Meeting, American College of Nutrition, San Antonio, USA
Y. Ueda, M. Masada (Chiba University) et al

“MGN-3 potentiates death receptor-induced apoptosis in cancer cells”

93rd Annual Meeting 2003 of American Association for Cancer Research, Boston, USA
Ghoneum M. (UCLA/Drew University of Medicine and Science) and S. Gollapudi (University of California Irvine)

“The effect of stimulation of natural killer cells on anemia of cancer patients”

2002 ASCO Annual Meeting, Orlando, USA
Amr A Elsaid (Alexandria University Hospital) et al

“The effect of modified rice-bran arabinoxylan on NK activity of human peripheral blood lymphocytes”

46th Japan Society for Bioscience, Biotechnology and Agrochemistry, Sendai, Japan
C. Shimomura (Graduate School of Science and Technology, Chiba University), Y. Ueda, H. Kodama, M. Masada (Department of Bioresources Chemistry, Chiba University) et al

“Study on the growth inhibiting component of cancerous cells in culture cell lines derived from modified rice-bran arabinoxylan”

46th Japan Society for Bioscience, Biotechnology, and Agrochemistry, Sendai, Japan
F. Miyazaki (Graduate School of Science and Technology, Chiba University), T. Hashizume (Kazami Co., Ltd), H. Kodama, M.Masada (Department of Bioresources Chemistry, Chiba University) et al

“Inhibitory effect of MGN-3 on the progress of atopic dermatitis in NC mice”

11th International Congress of Immunology, Stockholm, Sweden
S. Nonoyama  and L. Lin (Tokyo Medical and Dental University)

“MGN-3, a Novel Antitumor agent”

92nd Annual Meeting 2001 of American Association for Cancer Research, New Orleans, USA
K. Uyemura (UCLA/Drew University of Medicine and Science) et al

“Natural Biological Response Modifier (MGN-3) Shown To Be Effective Against Tumor Cell Growth”

8th International Congress on Anti-Aging & Biomedical Technologies, Las Vegas, USA
M.Ghoneum (UCLA/Drew University of Medicine and Science)

“Evaluation of Multiple Immunotherapies (including Arabinoxylan) Based on NK Cell Activity and CD4/CD8 Ratio in Cancer Patients”

The 3rd Annual Meeting of the Japanese Society for Complementary & Alternative Medicine & Treatment, Tokyo, Japan
K. Takahara (Nishi-Shinjuku Clinic) et al

“Inhibitory effects of MGN-3 (modified arabinoxylan from rice bran) on free radical”

59th Annual Meeting of the Japanese Cancer Association, Yokohama, Japan
T.Saito, H. Ohkami, K. Tsukada, K. Tazawa, H. Namikawa, S. Oida, J. Koike, M.Yatsuzuka (Toyama Medical and Pharmaceutical University), M. Masada (Chiba University) et al

“The Effect of MGN-3 on Cisplatin and Adriamycin Induced Toxicity in the Rat”

American Society for Pharmacology and Experimental Therapeutics, Boston, USA
H. Jacoby, G. Wnorowski (Product Safety Labs), K. Sakata (Creative Strategy, Inc.) et al

“The Effect of MGN-3 on Cisplatin and Adriamycin Induced Toxicity in the Rat”

101st Annual Meeting of the American Gastroenterological Association, San Diego, USA
H. Jacoby, G. Wnorowski (Product Safety Labs), K. Sakata (Creative Strategy, Inc.) et al

“Evaluation of MGN-3 (BioBran) with activation function of NK cell activity on Superoxide Scavenging Activity”

12th Japanese Conference on Bio Therapy, Yokohama, Japan
K. Tazawa (Toyama Medical and Pharmaceutical University ) et al

“Immunostimulation and Cancer Prevention”

7th International Congress on Anti-Aging & Biomedical Technologies, Las Vegas, USA
M.Ghoneum (UCLA/Drew University of Medicine and Science)

“Application of Modified Rice Bran Dietary Fiber to Diabetes and Taste Preference in Streptozotocin-Induced Diabetic Rats”

2nd International Conference on Food Factors, Kyoto, Japan
I. Ohara, K. Onai (Kobe Women’s University) et al

“Modified Rice Bran Improves Glucose Tolerance in NIDDM Adult Rats Given Streptozocin as Neonates”

American College of Nutrition 40th Annual Meeting, Washington DC, USA
I. Ohara, K. Onai (Kobe Women’s University) et al

“A Case in Which Rice Bran Arabinoxylan Was Used As A Supplemental Treatment When Curing Metastasis To Bones From Lung Cancer”

2nd Conference of Japanese Association for Alternative, Complementary and Traditional Medicine (JACT), Tokyo, Japan
T. Sobajima (Hoshigaoka Welfare Annuity Hospital) et al

“A Study of Active Oxygen Scavenging Activity of MGN-3 (BioBran)”

Methods in Kampo Pharmacology, 5th Shirakaba-ko Symposium, Nagano, Japan
K. Tazawa (Toyama Medical and Pharmaceutical University ) et al

“NK Immunorestration of Cancer Patients by MGN-3, a Modified Arabinoxylan Rice Bran (Study of 32 patients followed for up to 4 years)”

6th International Congress on Anti-Aging & Bio-Medical Technologies, Las Vegas, USA
M.Ghoneum (UCLA/Drew University of Medicine and Science)

“Active oxgen radical scavenging activity of the plant polysaccharide processed foodstuff BioBran”

3rd Japanese Society for Food Factors, Tokyo, Japan
K. Tazawa (Toyama Medical and Pharmaceutical University ) et al

“Immunopotentiation by utilization of MGN-3 tissue”

Congress on Anti-Aging Medicine, Reno, USA
M.Ghoneum (UCLA/Drew University of Medicine and Science)

“NK cell activity by MGN-3”

26th Academy of Alternative Medicine of Cancer, Los Angeles, USA
M.Ghoneum (UCLA/Drew University of Medicine and Science)

“Synergistic Effect of Modified Arabinoxylane (MGN-3) and Low Dose of Recombinant IL-2 Human NK Cell Activity and TNF-α Production”

American Academy of Anti-Aging Medicine, 1998 East Coast Conference, New Jersey, USA
M. Ghoneum and A. Jewett (UCLA/Drew University of Medicine and Science)

“MGN-3 Immunotherapy for the Treatment of Cancer”

The First International Symposium on Disease Prevention by IP6 & Other Rice Components, Kyoto, Japan
M.Ghoneum (UCLA/Drew University of Medicine and Science)

“The Effect of MGN-3, An Arabinoxylan Compound, on Serum Lipid in Streptozotocin Induced Diabetic Rats”

38th American Meeting of Nutrition Annual Meeting, New York, USA
I. Ohara (Kobe Women’s University) et al

“Anti-HIV activity by MGN-3 In Vitro”

11th International AIDS Conference, Vancouver, Canada
M. Ghoneum  (UCLA/Drew University of Medicine and Science)

“Effect of Human Natural Killer Cell Activity and Interferon-γ Synthesis in vitro”

ASBMB/ASIP/AAI JOINT MEETING, New Orleans, USA
M. Ghoneum (UCLA/Drew University of Medicine and Science) et al

“NK immunomodulatory function in 27 cancer patients by MGN-3, a modified arabinoxylan from rice bran”

87th Annual Meeting of the American Association for Cancer Research (AACR). Washington DC, USA
M. Ghoneum and N. Galal  (UCLA/Drew University of Medicine and Science)

“Immunomodulatory and Anti-Cancer Properties of (MGN-3), a modified xylose from rice bran, in 5 Patients with Breast Cancer”

American Association for Cancer Research Special Conference, Baltimore, USA
M.Ghoneum (UCLA/Drew University of Medicine and Science)