“Rice Bran Arabinoxylan Compound and Quality of Life (RBAC-QoL) of Cancer Patients: An Interim Analysis of the RBAC-QoL Study”

Soo Liang Ooi, Peter S. Micalos, Rob Zielinski, Sok Cheon Pak

Cureus 16(1): e53188. doi:10.7759/cureus.53188

“Importance of the Frequency at Using Immunomodulatory Therapies with　Evidence Based and Standardized Plant”

Tibor Hajto

Japanese Journal of Medical Research, 2023, Volume 1, Issue 2

“Efficiency of Biobran/MGN-3, an Arabinoxylan Rice Bran, in Attenuating Diabetes-Induced Cognitive Impairment of the Hippocampus via Oxidative Stress and IR/Akt/NF-kB in Rats”

Heba M. Abdou, Fatma A. Hamaad, Ghada M. Abd Elmageed, and Mamdooh H. Ghoneum

Evidence-Based Complementary and Alternative Medicine, vol. 2023, Article ID 8248576, 10 pages, 2023.

“Rice Bran: From Waste to Nutritious Food Ingredients”

Tan, Bee Ling, Mohd Esa Norhaizan, and Lee Chin Chan

Nutrients 2023, 15, 2503.

“Changes in the Human Gut Microbiome during Dietary Supplementation with Modified Rice Bran Arabinoxylan Compound”

Emily Schupfer, Soo Liang Ooi, Thomas C Jeffries, Shaoyu Wang, Peter S Micalos, Sok Cheon Pak

Molecules. 2023; 28(14):5400.

“Biobran/MGN-3, an Arabinoxylan Rice Bran, Protects against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An In Vitro and In Silico Study”

Mamdooh Ghoneum, Shaymaa Abdulmalek and Hewida H. Fadel

Nutrients 2023, 15(2), 453

“Is there any hepatic impact associated with rice bran arabinoxylan compound supplementation? A systematic review and dose–response meta-analysis of randomized controlled trials”

Morvarid Noormohammadi, Zeinab Ghorbani, Hossein Shahinfar, Farzad Shidfar

Clin Nutr ESPEN. 2023 Oct:57:665-675.

“Modified Rice Bran Arabinoxylan by Lentinus edodes Mycelial Enzyme as an Immunoceutical for Health and Aging-A Comprehensive Literature Review”

Ooi, Soo Liang, Peter S. Micalos, and Sok Cheon Pak

Molecules. 2023; 28(17):6313.

“Modified rice bran arabinoxylan as a nutraceutical in health and disease—A scoping review with bibliometric analysis”

Soo Liang Ooi,Peter S. Micalos,Sok Cheon Pak

PLoS One. 2023 Aug 31;18(8):e0290314.

“The Natural Killer Cell in Anticancer Therapy – An Important Role for Natural Compounds”

Professor Serge Jurasunas

Townsend Letter – AUGUST/SEPTEMBER 2022

“Enhancing effect of streptozotocin-induced insulin deficit on antitumor innate immune defense in rats”

Hajto Tibor, Péczely László, Kuzma Monika, Hormay Edina, Ollmann Tamás, Jaksó Pál, Baranyai Lilla and Karádi Zoltán

Research and Review Insights, 2022, Volume 6

“RBAC and Its Role with the Immune System”

Fred Pescatore, Carmelo Prestano, Malka Kichikova

ALTERNATIVE THERAPIES, JANUARY 2022 VOL. 28 NO. 1

“BioBran, Immuno Modulating Rice Bran Arabinoxylan Compound: Functions and Evidence”

Naoki Igari

Food processing and ingredients,  Vol.55, No.10

“Effect of rice bran arabinoxylan on immunity”

Naoki Igari

FOOD Style 21, January,  2021 （Vol.25 No.1）

“Protective Effect of Biobran/MGN-3 against Sporadic Alzheimer’s Disease Mouse Model: Possible Role of Oxidative Stress and Apoptotic Pathways”

Mamdooh H. Ghoneum Nesrine S. El Sayed

Hindawi Oxidative Medicine and Cellular Longevity Volume 2021, Article ID 8845064, 15 pages

“Dietary Supplementation with Biobran/MGN-3 Increases Innate Resistance and Reduces the Incidence of Influenza-like Illnesses in Elderly Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Clinical Trial”

Ahmed F. Elsaid, Sudhanshu Agrawal, Anshu Agrawal and Mamdooh Ghoneum

Nutrients 2021, 13, 4133

“The Health-Promoting Properties and Clinical Applications of Rice Bran Arabinoxylan Modified with Shiitake Mushroom Enzyme—A Narrative Review”

Soo Liang Ooi, Sok Cheon Pak , Peter S. Micalos, Emily Schupfer, Catherine Lockley 1 ,Mi Houn Park and Sung-Joo Hwang

Molecules 2021 Apr 27;26(9):2539.

“Standardized Plant Immunomodulator Increases the Effect of MEK and BRAF Inhibitors with Clinical Benefit. Case Report of a Patient with Carcinoma in Biliary Duct”

T. Hajto

Biomedical Research and Clinical Reviews Auctores Publishing, 2020

“Can standardized and evidence based plant immunomodulator (rice bran arabinoxylan concentrate)
increase the effect of Gemcitabine in a synergistic manner? Case report of a patient with ductal pancreas carcinoma”

T. Hajto

Res Rev Insights, 2020

“Chemopreventive role of arabinoxylan rice bran, MGN-3/Biobran, on liver carcinogenesis in rats”

M. Ghoneum et al.

Biomedicine & Pharmacotherapy, 126, 2020

“The Immunomodulating Effects of Arabinoxylan Rice Bran (Lentin) on Hematologic Profile, Nutritional Status and Quality of Life among Head and Neck Carcinoma Patients Undergoing Radiation Therapy: A Double Blind Randomized Control Trial”

Dorothy Faye S. Tan, Jerickson Abbie S. Flores, Jose R. Reyes

Radiology Journal 12, 2020

“Arabinoxylan rice bran (MGN-3/Biobran) alleviates radiation-induced intestinal barrier dysfunction of mice in a mitochondrion-dependent manner”

Zhenguo Zhao, Wei Cheng, Wei Qu, Kai Wang

Biomedicine & Pharmacotherapy, 124, 2020

“Cardiovascular, endothelial function, and immune markers in response to treatment with a polysaccharide in HIV+ adults in a randomized, doubleblind placebo-controlled trial”

John E. Lewis, Steven E. Atlas, Muhammad H. Abbas, Ammar Rasul, Ashar Farooqi, Laura A. Lantigua, Frederick Michaud1, Sharon Goldberg, Lucas C. Lages, Jinrun Gao, Oscar L. Higuera, Andrea Fiallo, Philip D. Harvey, Eduard Tiozzo, Judi M. Woolger, Stephanie Ciraula, Armando Mendez, Allan Rodriguez, Janet Konefal

Journal of Clinical and Translational Research 2020; 5(3): 140-147

“Arabinoxylan rice bran (MGN-3/Biobran) enhances radiotherapy in animals bearing Ehrlich ascites carcinoma”

Nariman K. Badr El-Din, Said K. Areida, Kvan O. Ahmed

Journal of Radiation Research, 2019

“The Novel Effects of a Hydrolyzed Polysaccharide Dietary Supplement on Immune, Hepatic, and Renal Function in Adults with HIV in a Randomized, Double-Blind Placebo-Control Trial”

J. Lewis, et al.

Journal of Dietary Supplements, 2018

“New Perspectives to Improve the MHC-I Unrestricted Immune Mechanisms against Malignant Tumors”

T. Hajto

Advances in Clinical and Translational Research Volume 2, Issue 3, 2018

“The Effect of a Hydrolyzed Polysaccharide Dietary Supplement on Biomarkers in Adults with Nonalcoholic Fatty Liver Disease”

J. Lewis, et al.

Evidence-Based Complementary and Alternative Medicine Volume 2018, 2018

“Urgent Necessity for Standardized and Evidence Based Plant Immunomodulators (Such As Rice Bran Arabinoxylan Concentrate/MGN-3) for the Tumor Research”

T. Hajto

Internationa Journal of Complementary & Alternative Medicine Volume 9 Issue 3, 2017

“Evidence-Based Review of BioBran/MGN-3 Arabinoxylan Compound as a Complementary Therapy for Conventional Cancer Treatment”

S.L. Ooi, D. McMullen, T. Golombick, S.C. Pak

Integrative Cancer Therapies  1–14, 2017

“Can a standardized plant immunomodulator (rice bran arabinoxylan concentrate/MGN-3) increase the effects of MEK and BRAF inhibitors with clinical benefit? Case report of a patient with carcinoma in biliary duct”

T. Hajto

Research and Review Insights, Volume 1(3), 1-4, 2017

“Modified rice bran hemicellulose inhibits vascular endothelial growth factor-induced angiogenesis in vitro via VEGFR2 and its downstream signaling pathways”

X. Zhu et al.

Bioscience of Microbiota, Food and Health Vol. 36 (2), 45–53, 2017

“Arabinoxylan rice bran (Biobran) suppresses the viremia level in patients with chronic HCV infection: A randomized trial*”

H. Salama, E. Medhat, M. Shaheen, Abdel-Rahman N Zekri, T. Darwish, M. Ghoneum

International Journal of Immunopathology and Pharmacology 1–7

“From Bench to Bedside: The Growing Use of Arabinoxylan Rice Bran (MGN-3/Biobran) in Cancer Immunotherapy”

M. Ghoneum

Austin Immunol – Volume 1 Issue 2

“Can the EGFR inhibitors increase the immunomodulatory effects of standardized plant extracts (mistletoe lectin and arabonoxylan) with clinical benefit? Case report of a patient with lung adenocarcinoma”

T. Hajto, A.Horváth, L. Baranyai, M. Kuzma, P. Perjési

Clinical Case Reports and Reviews Volume 2(6): 456-459

“Addition of Rice Bran Arabinoxylan to Curcumin Therapy May Be of Benefit to Patients With Early-Stage B-Cell Lymphoid Malignancies (Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma, or Stage 0/1 Chronic Lymphocytic Leukemia):A Preliminary Clinical Study”

T. Golombick, T. H. Diamond, A. Manoharan, R. Ramakrishna

Integrative Cancer Therapies January-March 2016: 1–7

“Chemopreventive Activity of MGN-3/Biobran Against Chemical Induction of Glandular Stomach Carcinogenesis in Rats and Its Apoptotic Effect in Gastric Cancer Cells”

Nariman K. Badr El-Din, S. M. Abdel Fattah, D. Pan, L. Tolentino, M. Ghoneum

Integrative Cancer Therapies April-June 2016: 1–9

“Improvement of Quality of Life in Tumor Patients after an Immunomodulatory Treatment with Standardized Mistletoe Lectin and Arabinoxylan Plant Extracts”

T. Hajto, A. Horváth, S. Papp

International Journal of Neurorehabilitation Vol.3, doi:10.4172/2376-0281.1000205

“Can a synergistic activation of pattern recognition receptors by plant immunomodulators enhance the effect of oncologic therapy? Case Report of a patient with uterus and ovary sarcoma”

T. Hajto, L. Baranyai, A. Kirsch, M. Kuzma, P. Perjesi

Clin Case Rep Rev, Vol. 1 (10), 235-238

“Arabinoxylan rice bran (MGN-3/Biobran) enhances natural killer cell-mediated cytotoxicity against neuroblastoma, in vitro and in vivo”

R. Handgretinger, M. M. Pfeiffer, et al.

Cytotherapy, 2015

MGN-3/biobran enhances generation of cytotoxic CD8+ T cells via upregulation of dec-205 expression on dendritic cells

M. Ghoneum, S. Agrawal

International Journal of Immunopathology and Pharmacology, Vol.27, No.4, 523-530, 2014

“Therapeutic Effects of BioBran, Modified Arabinoxylan Rice Bran, in Improving Symptoms of Diarrhea Predominant or Mixed Type Irritable Bowel Syndrome: A Pilot, Randomized Controlled Study”

T. Kamiya, et al.

Evidence-Based Complementary and Alternative Medicine, 2014

“Modified Arabinoxylan from Rice Bran, MGN-3/Biobran, sensitizes Metastatic Breast Cancer Cells to Paclitaxel in Vitro”

M. Ghoneum et al

Anticancer Research, 34, 81-88

“Case Reports of Cancer Patients with Hepatic Metastases Treated by Standard Plant Immunomodulatory Preparations”

T. Hajito, A. Kirsch

Journal of Cancer Research Updates, 2, 1-9

“”BIOBRAN MGN-3″; Effect of reducing side effects of chemotherapy in breast cancer patients”

Dr. Ahmad Ijaz Masood, Dr. Rabeeta Sheikh, Dr. Rana Atique Anwer

The Profesional Medical Journal Jan-Feb 2013;20(1): 013-016

“A case of stage IV hepatocellular carcinoma treated by KM900, Biobran, and psychotherapy has presented significant good results”

K. Meshitsuka

Personalized Medicine Universe (Japanese Edition) vol. 1, No. 1, 46-48

“Arabinoxylan rice bran(MGN-3/Biobran) provides protection against whole-body γ-irradiation in mice via restoration of  hematopoietic tissues”

M. Ghoneum et al
Journal of Radiation Research

“MGN-3 arabinoxylan rice bran modulates innate immunity in multiple myeloma patients”

D. Cholujova et al
Cancer Immunol Immunother, Mar, 62(3), 437-445

“Evaluation of a flow cytometry-based assay for natural killer cell activity in clinical settings”

Valiathan, R., Lewis, J. E., Melillo A., Leonard S., Ali, K. H., & Asthana, D.

Scandinavian Journal of Immunology, 75, 455-462.

“Protective effect of low molecular fraction of MGN-3, a modified arabinoxylan from rice bran,on acute liver injury by inhibition of NF-кB and JNK/MAPK expression”

S.Zheng, S. Sugita, S. Hirai, and Y. Egashira
International Immunopharmacology, 14, 764-769

“An open-label, randomized clinical trial to assess the immunomodulatory activity of a novel oligosaccharide compound in healthy adults”

J. Lewis et al
Functional Foods in Health and Disease, 2(7), 265-279

“Suppressive Effect of Modified Arabinoxylan from Rice Bran (MGN-3) on D-Galactosamine-Induced IL-18 Expression and Hepatitis in Rats”

Y. Egashira et al
Bioscience Biotechnology and Biochemistry, 76(5), 942-946

“ACTIVATION OF HUMAN MONOCYTE-DERIVED DENDRITIC CELLS IN VITRO BY THE BIOLOGICAL RESPONSE MODIFIER ARABINOXYLAN RICE BRAN(MGN-3/BIOBRAN)”

M. Ghoneum, S. Agrawal
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY 24(4), 941-948

“Synergistic apoptotic effect of Arabinoxylan rice bran(MGN-3/Biobran)and Curcumin(Turmeric) on human multiple myelanoma cell line U266 in vivo”

M. Ghoneum, S. Gollapudi
Neoplasma, 58, 2

“Arabinoxylan Rice Bran(MGN-3) Enhances the Effects of Interventional Therapies for the Treatment of Hepatocellular Carcinoma: A Three-year Randomized Clinical Trial”

M. Ghoneum, M. Bang, et al
Anticancer Research, 30, 12, 5145-5152

“Functionality of Biobran (Rice Bran Arabinoxylan) – Focusing on the Promotion Effect of Dendiritic Cell Maturation”

H. Kato, et al
New Food Industry, 52, 6, 17-23

“BioBran-augmented maturation of human monocyte-derived dendritic cells”

D. Cholujova, et al
Neoplasma, 56, 2, 89-96

“Antioxidant potential by arabinoxylan rice bran, MGN-3/biobran, represents a mechanism for its oncostatic effect against solid Ehrlich carcinoma”

M. Ghoneum, et al
Cancer Letters, 268(2), 348-359

“Modified Arabinoxylan Rice Bran (MGN-3/BioBran) Enhances Intracellular Killing Microbes by Human Phagocytic Cells in Vitro”

M.Ghoneum, M.Matuura and S.Gollapudi
International Journal of Immunopathology and Pharmacology, 21, 1, 87-95

“In Vivo Tumor Inhibitory Effects of Nutritional Rice Bran Supplement MGN-3/Biobran on Ehrlich Carcinoma-Bearing Mice”

M. Ghoneum, et al
Nutrition and Cancer, 60(2), 235-244

“MGN-3/Biobran,modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin”

S. Gollapudi, M. Ghoneum, et al
Cancer Detection and Prevention, 32, 1-6

“Metastatic Hemangiopericytoma of the Skin Treated with Wide Local Excision and MGN-3”

J. Markus, A. Miller, M. Smith, I.  Orengo
Dermatologic Surgery, 32, 145-147

“Modified Arabinoxylan Rice Bran (MGN-3/BioBran)  Enhances Yeast-induced Apoptosis in Human Breast Cancer Cells In Vitro”

M. Ghoneum, S. Gollapudi
Anticancer Research, 25, 859-870

“Experience with Administration of BioBran in Patients with Chronic Rheumatism”

K. Ichihashi
Clinical Pharmacology and Therapy, 14, 4, 459-463

“The Life Prolongation and QOL Improvement Effect of Rice Bran Arabinoxylan Derivative (MGN-3, BioBran) for Progressive Cancer”

K. Takahara, et al
Clinical Pharmacology and Therapy, 14, 3, 267-271

“A Case Where an Immunomodulatory Food was Effective in Conservative Therapy for Progressive Terminal Pancreatic Cancer”

K. Kaketani
Clinical Pharmacology and Therapy, 14, 3, 273-279

“One Case of a Patient with Umbilical Metastasis of Recurrent Cancer (Sister Mary Joseph’s Nodule, SMJN) Who has Survived for a Long Time under Immnomodulatory Supplement Therapy”

T. Kawai
Clinical Pharmacology and Therapy, 14, 3, 281-288

“The Clinical Significance of BioBran in the Immunotherapy for Cancer”

Y. Okamura
Clinical Pharmacology and Therapy, 14, 3, 289-294

“Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/BioBran)”

M. Ghoneum, S. Abedi
Journal of Pharmacy and Pharmacology, 56, 12, 1581-1588

“Augmentation of Macrophage Phagocytosis by Modified Arabinoxylan Rice Bran (MGN-3/BioBran)”

M. Ghoneum, M. Matsuura
International Journal of Immunopathology and Pharmacology, 17, 3, 283-292

“Modified arabinoxylan rice bran (MGN-3/BioBran) sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis”

M. Ghoneum, S. Gollapudi
Cancer Letters, 201, 41-49

“Modified Rice Bran Beneficial for Weight Loss of Mice as a Major and Acute Adverse Effect of Cisplatin”

Y. Endo, H. Kanbayashi
Pharmacology and Toxiology, 92, 300-303

“Modified Rice Bran Improves Glucose Tolerance in NIDDM Adult Rats Given Streptozocin as Neonates”

I. Ohara, et al
Aichi Gakusen University collected papers, 37, 17-23

“The basic study of arabinoxylan compound (MGN-3) on the activation of vital defense”

N. Sudo, et al
Clinical Research, 78, 1, 193-196

“The Effect of MGN-3 on Cisplatin and Doxorubicin Induced Toxicity in the Rat”

H. I. Jacoby, G. Wnorowski, K. Sakata, et al
Journal of Nutraceuticals, Functional & Medical Foods, 3(4)

“Effects of Modified Rice Bran on Serum Lipids and Taste Preference in Streptozocin-induced Diabetic Rats”

I. Ohara, R. Tabuchi, K. Onai
Nutrition Research, 20, 1, 59-66

“Production of Tumor Necrosis Factor-α and Interferon-γ from Human Peripheral Blood Lymphocytes by MGN-3, Modified Arabinoxylan from Rice Bran, and Its Synergy with Interleukin-2 In Vitro”

M. Ghoneum, A. Jewett
Cancer Detection and Prevention, 24, 4, 314-324

“NK Inmmunorestration of Cancer patients by MGN-3, a Modified Arabinoxylane Rice Bran (Study of 32 Patients up to 4 years)”

M. Ghoneum, J. Brown
Anti-Aging Medical Therapeutics, 3, 217-216

“Anti-HIV activity in Vitro of MGN-3 an Activated Arabinoxylan from Rice Bran”

M. Ghoneum
Biochemical & Biophysical Research Commnunication, 243, 25-29

“Enhancement of Human Natural Killer Cell activity by Modified Arabinoxylan from Rice Bran”

M. Ghoneum
International Journal of Immunotherapy, XV, 2, 89-99