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Published Research Papers Academic Presentations

Published Research Papers Academic Presentations

BioBran-Academic Presentations



2016

“Arabinoxylan rice bran (Biobran) suppresses the viremia level in patients with chronic HCV infection: A randomized trial*”

H. Salama, E. Medhat, M. Shaheen, Abdel-Rahman N Zekri, T. Darwish, M. Ghoneum

International Journal of Immunopathology and Pharmacology 1–7

2016

“From Bench to Bedside: The Growing Use of Arabinoxylan Rice Bran (MGN-3/Biobran) in Cancer Immunotherapy”

M. Ghoneum

Austin Immunol – Volume 1 Issue 2

2016

“Can the EGFR inhibitors increase the immunomodulatory effects of standardized plant extracts (mistletoe lectin and arabonoxylan) with clinical benefit? Case report of a patient with lung adenocarcinoma”

T. Hajto, A.Horváth, L. Baranyai, M. Kuzma, P. Perjési

Clinical Case Reports and Reviews Volume 2(6): 456-459

2016

“Addition of Rice Bran Arabinoxylan to Curcumin Therapy May Be of Benefit to Patients With Early-Stage B-Cell Lymphoid Malignancies (Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma, or Stage 0/1 Chronic Lymphocytic Leukemia):A Preliminary Clinical Study”

T. Golombick, T. H. Diamond, A. Manoharan, R. Ramakrishna

Integrative Cancer Therapies January-March 2016: 1–7

2016

“Chemopreventive Activity of MGN-3/Biobran Against Chemical Induction of Glandular Stomach Carcinogenesis in Rats and Its Apoptotic Effect in Gastric Cancer Cells”

Nariman K. Badr El-Din, S. M. Abdel Fattah, D. Pan, L. Tolentino, M. Ghoneum

Integrative Cancer Therapies April-June 2016: 1–9

 

2016

“Improvement of Quality of Life in Tumor Patients after an Immunomodulatory Treatment with Standardized Mistletoe Lectin and Arabinoxylan Plant Extracts”

T. Hajto, A. Horváth, S. Papp

International Journal of Neurorehabilitation Vol.3, doi:10.4172/2376-0281.1000205

 

2015

“Can a synergistic activation of pattern recognition receptors by plant immunomodulators enhance the effect of oncologic therapy? Case Report of a patient with uterus and ovary sarcoma”

T. Hajto, L. Baranyai, A. Kirsch, M. Kuzma, P. Perjesi

Clin Case Rep Rev, Vol. 1 (10), 235-238

2015

“Arabinoxylan rice bran (MGN-3/Biobran) enhances natural killer cell-mediated cytotoxicity against neuroblastoma, in vitro and in vivo

R. Handgretinger, M. M. Pfeiffer, et al.

Cytotherapy, 2015

2014

MGN-3/biobran enhances generation of cytotoxic CD8+ T cells via upregulation of dec-205 expression on dendritic cells

M. Ghoneum, S. Agrawal

International Journal of Immunopathology and Pharmacology, Vol.27, No.4, 523-530, 2014

2014

“Therapeutic Effects of BioBran, Modified Arabinoxylan Rice Bran, in Improving Symptoms of Diarrhea Predominant or Mixed Type Irritable Bowel Syndrome: A Pilot, Randomized Controlled Study”

T. Kamiya, et al.

Evidence-Based Complementary and Alternative Medicine, 2014

2014

“Modified Arabinoxylan from Rice Bran, MGN-3/Biobran, sensitizes Metastatic Breast Cancer Cells to Paclitaxel in Vitro

M. Ghoneum et al

Anticancer Research, 34, 81-88

2013

“Case Reports of Cancer Patients with Hepatic Metastases Treated by Standard Plant Immunomodulatory Preparations”

T. Hajito, A. Kirsch

Journal of Cancer Research Updates, 2, 1-9

2013

“”BIOBRAN MGN-3″; Effect of reducing side effects of chemotherapy in breast cancer patients”

Dr. Ahmad Ijaz Masood, Dr. Rabeeta Sheikh, Dr. Rana Atique Anwer

The Profesional Medical Journal Jan-Feb 2013;20(1): 013-016

 

2013

“A case of stage IV hepatocellular carcinoma treated by KM900, Biobran, and psychotherapy has presented significant good results”

K. Meshitsuka

Personalized Medicine Universe (Japanese Edition) vol. 1, No. 1, 46-48

2013

“Arabinoxylan rice bran(MGN-3/Biobran) provides protection against whole-body γ-irradiation in mice via restoration of  hematopoietic tissues”

M. Ghoneum et al
Journal of Radiation Research

2013

“MGN-3 arabinoxylan rice bran modulates innate immunity in multiple myeloma patients”

D. Cholujova et al
Cancer Immunol Immunother, Mar, 62(3), 437-445

2012

“Protective effect of low molecular fraction of MGN-3, a modified arabinoxylan from rice bran,on acute liver injury by inhibition of NF-кB and JNK/MAPK expression”

S.Zheng, S. Sugita, S. Hirai, and Y. Egashira
International Immunopharmacology, 14, 764-769

2012

“An open-label, randomized clinical trial to assess the immunomodulatory activity of a novel oligosaccharide compound in healthy adults”

J. Lewis et al
Functional Foods in Health and Disease, 2(7), 265-279

2012

“Suppressive Effect of Modified Arabinoxylan from Rice Bran (MGN-3) on D-Galactosamine-Induced IL-18 Expression and Hepatitis in Rats”

Y. Egashira et al
Bioscience Biotechnology and Biochemistry, 76(5), 942-946

2011

“ACTIVATION OF HUMAN MONOCYTE-DERIVED DENDRITIC CELLS IN VITRO BY THE BIOLOGICAL RESPONSE MODIFIER ARABINOXYLAN RICE BRAN(MGN-3/BIOBRAN)”

M. Ghoneum, S. Agrawal
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY 24(4), 941-948

2011

“Synergistic apoptotic effect of Arabinoxylan rice bran(MGN-3/Biobran)and Curcumin(Turmeric) on human multiple myelanoma cell line U266 in vivo

M. Ghoneum, S. Gollapudi
Neoplasma, 58, 2

2010

“Arabinoxylan Rice Bran(MGN-3) Enhances the Effects of Interventional Therapies for the Treatment of Hepatocellular Carcinoma: A Three-year Randomized Clinical Trial”

M. Ghoneum, M. Bang, et al
Anticancer Research, 30, 12, 5145-5152

2010

“Functionality of Biobran (Rice Bran Arabinoxylan) – Focusing on the Promotion Effect of Dendiritic Cell Maturation”

H. Kato, et al
New Food Industry, 52, 6, 17-23

2009

“BioBran-augmented maturation of human monocyte-derived dendritic cells”

D. Cholujova, et al
Neoplasma, 56, 2, 89-96

2008

“Antioxidant potential by arabinoxylan rice bran, MGN-3/biobran, represents a mechanism for its oncostatic effect against solid Ehrlich carcinoma”

M. Ghoneum, et al
Cancer Letters, 268(2), 348-359

2008

“Modified Arabinoxylan Rice Bran (MGN-3/BioBran) Enhances Intracellular Killing Microbes by Human Phagocytic Cells in Vitro

M.Ghoneum, M.Matuura and S.Gollapudi
International Journal of Immunopathology and Pharmacology, 21, 1, 87-95

2008

“In Vivo Tumor Inhibitory Effects of Nutritional Rice Bran Supplement MGN-3/Biobran on Ehrlich Carcinoma-Bearing Mice”

M. Ghoneum, et al
Nutrition and Cancer, 60(2), 235-244

2008

“MGN-3/Biobran,modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin”

S. Gollapudi, M. Ghoneum, et al
Cancer Detection and Prevention, 32, 1-6

2006

“Metastatic Hemangiopericytoma of the Skin Treated with Wide Local Excision and MGN-3″

J. Markus, A. Miller, M. Smith, I.  Orengo
Dermatologic Surgery, 32, 145-147

2005

“Modified Arabinoxylan Rice Bran (MGN-3/BioBran)  Enhances Yeast-induced Apoptosis in Human Breast Cancer Cells In Vitro”

M. Ghoneum, S. Gollapudi
Anticancer Research, 25, 859-870

2004

“Experience with Administration of BioBran in Patients with Chronic Rheumatism”

K. Ichihashi
Clinical Pharmacology and Therapy, 14, 4, 459-463

2004

“The Life Prolongation and QOL Improvement Effect of Rice Bran Arabinoxylan Derivative (MGN-3, BioBran) for Progressive Cancer”

K. Takahara, et al
Clinical Pharmacology and Therapy, 14, 3, 267-271

2004

“A Case Where an Immunomodulatory Food was Effective in Conservative Therapy for Progressive Terminal Pancreatic Cancer”

K. Kaketani
Clinical Pharmacology and Therapy, 14, 3, 273-279

2004

“One Case of a Patient with Umbilical Metastasis of Recurrent Cancer (Sister Mary Joseph’s Nodule, SMJN) Who has Survived for a Long Time under Immnomodulatory Supplement Therapy”

T. Kawai
Clinical Pharmacology and Therapy, 14, 3, 281-288

2004

“The Clinical Significance of BioBran in the Immunotherapy for Cancer”

Y. Okamura
Clinical Pharmacology and Therapy, 14, 3, 289-294

2004

“Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/BioBran)”

M. Ghoneum, S. Abedi
Journal of Pharmacy and Pharmacology, 56, 12, 1581-1588

2004

“Augmentation of Macrophage Phagocytosis by Modified Arabinoxylan Rice Bran (MGN-3/BioBran)”

M. Ghoneum, M. Matsuura
International Journal of Immunopathology and Pharmacology, 17, 3, 283-292

2003

“Modified arabinoxylan rice bran (MGN-3/BioBran) sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis”

M. Ghoneum, S. Gollapudi
Cancer Letters, 201, 41-49

2003

“Modified Rice Bran Beneficial for Weight Loss of Mice as a Major and Acute Adverse Effect of Cisplatin”

Y. Endo, H. Kanbayashi
Pharmacology and Toxiology, 92, 300-303

2002

“Modified Rice Bran Improves Glucose Tolerance in NIDDM Adult Rats Given Streptozocin as Neonates”

I. Ohara, et al
Aichi Gakusen University collected papers, 37, 17-23

2001

“The basic study of arabinoxylan compound (MGN-3) on the activation of vital defense”

N. Sudo, et al
Clinical Research, 78, 1, 193-196

2001

“The Effect of MGN-3 on Cisplatin and Doxorubicin Induced Toxicity in the Rat”

H. I. Jacoby, G. Wnorowski, K. Sakata, et al
Journal of Nutraceuticals, Functional & Medical Foods, 3(4)

2000

“Effects of Modified Rice Bran on Serum Lipids and Taste Preference in Streptozocin-induced Diabetic Rats”

I. Ohara, R. Tabuchi, K. Onai
Nutrition Research, 20, 1, 59-66

2000

“Production of Tumor Necrosis Factor-α and Interferon-γ from Human Peripheral Blood Lymphocytes by MGN-3, Modified Arabinoxylan from Rice Bran, and Its Synergy with Interleukin-2 In Vitro”

M. Ghoneum, A. Jewett
Cancer Detection and Prevention, 24, 4, 314-324

1999

“NK Inmmunorestration of Cancer patients by MGN-3, a Modified Arabinoxylane Rice Bran (Study of 32 Patients up to 4 years)”

M. Ghoneum, J. Brown
Anti-Aging Medical Therapeutics, 3, 217-216

1999

“Anti-HIV activity in Vitro of MGN-3 an Activated Arabinoxylan from Rice Bran”

M. Ghoneum
Biochemical & Biophysical Research Commnunication, 243, 25-29

1998

“Enhancement of Human Natural Killer Cell activity by Modified Arabinoxylan from Rice Bran”

M. Ghoneum
International Journal of Immunotherapy, XV, 2, 89-99