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Published Research Papers Academic Presentations

Published Research Papers Academic Presentations

NKCP-Academic Presentations



2023

“Effects of Dietary Bacillus natto Productive Protein on the Skin: In Vitro Efficacy Test and Single-Armed Trial”

Naoki Igari, Ryo Ninomiya, Satoshi Kawakami

Cosmetics. 2023; 10(5):135.

2022

“Effects of Bacillus subtilis Var. Natto Products on Capillary Blood Flow in Healthy Subjects with Peripheral Coldness: A Double-Blind, Placebo-Controlled, Randomized Parallel Study”

Chiharu Fujita, Yukio Usui, Masanori Inoue

Food and Nutrition Sciences, 2022, 13, 211-223

2021

“Effects of purified filtrate of Bacillus subtilis var. natto culture (NKCP) on the lectin-like oxidized low-density lipoprotein receptor index (LOX index)”

Kazutoshi Kaketani

FOOD FUNCTION Vol. 17, 2021 2-5

2020

“A Functional Food for Metabolic Disorders”

F. Pescatore

TOWNSEND LETTER – AUGUST/SEPTEMBER 2020, 2020

2018

“How a Novel Protease Produced by Bacillus subtilis natto Improves Blood Flow: Subjective Symptoms in Lifestyle-Associated Disease”

M. Hitosugi

Bacillus subtilis:Morphology, Functions and Role in Disease Management, Chapter 4, 2018

2018

“Effects of products containing Bacillus subtilis var. natto on healthy subjects with neck and shoulder stiffness, a double-blind, placebo-controlled, randomized crossover study”

Y. Sunagawa, N. Okamura, Y. Miyazaki, K. Shimizu, M. Genpei, M. Funamoto, S. Shimizu, Y. Katanasaka, E.Morimoto, H. Yamakage, M. Komiyama, N. Satoh-Asahara, H. Wada, M. Suzuki, K. Hasegawa, T. Morimoto

Biological and Pharmaceutical Bulletin, 2018

2015

Effects of Bacillus subtilis var. natto products on symptoms caused by blood flow disturbance in female patients with lifestyle diseases

M. Hitosugi, K. Hamada, K. Misaka

International Journal of General Medicine,  2015:8 41–46, 2015.

2014

“Effects of Bacillus Natto Products on Blood Pressure in Patients with Lifestyle Diseases”

M. Hitosugi, K. Hamada, K. Misaka and Ichihashi K.

Journal of Hypertension Open Access, 3, 1

2013

“Action of the purified filtrate of Bacillus subtilis var. natto culture”

N. Igari, X. Zhu, K. Ninomiya

Food Style 21, 17, 11

2008

“Changes in subjective symptoms with ingestion of NKCP”

M. Hitosugi, H. Kato, X. Zhu and Tokudome S.
Food Function, 4(2), 1-4

2007

“Anticoagulant and fibrinolytic effects of functional food materials produced by Bacillus subtilis natto”

M. Hitosugi, I. Ikeda, X. Zhu, H. Kato, K. Omura, T. Nagai and Tokudome S.
Journal of Japanese Society of Biorheology, 21, 1

2006

“Determination of bacillopeptidase F, a protein produced by Bacillus subtilis natto, using ELISA”

X. Zhu, M. Hashimoto, R. Sekiguchi, M. Yamamoto, E. Araki, K. Omura and Kato H.
Journal of Nutrition Food, 9, 3/4

2006

“Interaction between warfarin and functional foods derived from Bacillus subtilis natto

M. Hitosugi, X. Zhu, H. Kato and Tokudome S.
Food Style21, 10, 9

2005

“A Newly Derived Protein From Bacillus subtilis natto With Both Antithrombotic and Fibrinolytic Effects”

K. Omura, M. Hitosugi, X. Zhu, M. Ikeda, H. Maeda and Tokudome S.
Journal of Pharmacological Sciences, 99, 247-251

2004

“Fibrinolytic and anti-thrombotic effect of NKCP, the protein layer from Bacillus subtilis (natto)”

K. Omura, M. Hitosugi, K. Kaketani, X. Zhu, H. Maeda and Tokudome S.
BioFactors, 22, 1-4, 185-187

2004

“The Effect of Dietary Bacillus Natto Productive Protein on in vivo Endogenous Thrombolysis”

T. Yamashita, E. Oda, J.C. Giddings and Yamamoto J.
Phathophysiology of Haemostasis and Thrombosis, 33, 138-143

2004

“Determination of the Thrombolytic Activity of Natto Extract”

M. Masada
Food Style21, 8, 1

2004

“Fibrinolytic and antithrombotic effect of the protein from Bacillus subtilis (natto) by the oral administration”

K. Omura, K. Kaketani, H. Maeda and Hitosugi M.
Journal of the Japanese Society of Biorheology, 18, 1

2002

“Effect of dried filtrate of natto bacilli culture “NKCP” on blood fluidity”

T. Hayashi, C. Takahashi and Kikuchi Y.
Journal of the Japanese Society of Hemorheology, 5, 43-45

2001

“Changes in Blood Viscosity by Heparin and Argatoban”

M. Hitosugi, M. Niwa and Takatsu A.
Thrombosis Research, 104, 371-374

2000

“Rheologic Changes in Venous Blood During Prolonged Sitting”

M. Hitosugi, M. Niwa and Takatsu A.
Thrombosis Research, 100, 409-412

1978

“Warfarin Antagonism by the fermented soybeans Natto in Anticoagulant Therapy”

T. Kudo, Y. Uchibori, K. Atumi, Y. Numano, I. Miura, M. Shitara and Hashimoto A.
Journal of Clinical and Experimental Medicine, 104, 36-38